Srimad-Bhagavatam: Canto 5 - Chapter 1 - Verse 25

Sanskrit:

क्‍वचिच्च शीतवाताद्यनेकाधिदैविकभौतिकात्मीयानां दशानां प्रतिनिवारणेऽकल्पो दुरन्तचिन्तया विषण्ण आस्ते ॥ २५ ॥

ITRANS:

kvacic ca śīta-vātādy-anekādhidaivika-bhautikātmīyānāṁ daśānāṁ pratinivāraṇe ’kalpo duranta-cintayā viṣaṇṇa āste.

Translation:

Being unable to protect himself from the threefold miseries of material existence, the conditioned soul becomes very morose and lives a life of lamentation. These threefold miseries are miseries suffered by mental calamity at the hands of the demigods [such as freezing wind and scorching heat], miseries offered by other living entities, and miseries arising from the mind and body themselves.

Purport:

The so-called happy materialistic person is constantly having to endure the threefold miseries of life, called adhidaivika, adhyātmika and adhibhautika. Actually no one can counteract these threefold miseries. All three may assail one at one time, or one misery may be absent and the other present. Thus the living entity is full of anxiety, fearing misery from one side or the other. The conditioned soul must be disturbed by at least one of these three miseries. There is no escape.